# Buy MOTS-C 40 mg in Australia Supplied by Australian Research Peptides Pty Ltd to laboratories and researchers in Australia, for in vitro research purposes only. Stock is held and dispatched within Australia. In Australia, MOTS-C comes from Australian Research Peptides in sealed, freeze-dried 40 mg vial for laboratories and researchers — $149.99, in stock; payment received before 12pm Sydney time on a business day means same-day dispatch. The MOTS-C 40 mg certificate states 99.234% purity. MOTS-C is a sixteen-amino-acid chain coded inside mitochondria rather than the nucleus, studied in cellular energy-metabolism research. Its reported molecular target is AMPK, a fuel-sensing protein, and skeletal muscle is the tissue most often examined. It is HPLC-tested and checked by mass spectrometry. In vitro research purposes only — not for human or animal use. Research context: energy metabolism. ## Strengths, prices and availability | Strength | Price (AUD) | Availability | SKU | | --- | --- | --- | --- | | 40 mg | $149.99 | In stock | 58106 | ## Certificate of analysis Tested by Janoshik, an independent laboratory, before release. The testing is commissioned by the manufacturer rather than by Australian Research Peptides. Methods: HPLC for purity, mass spectrometry for identity. Each certificate below is the laboratory's own report, published on this site. ### 40 mg - Assayed purity: 99.234% - Measured peptide content: 46.46 mg - Laboratory batch: 2026-06 - Date analysed: 19 June 2026 - Testing laboratory: Janoshik - Certificate: https://www.australianresearchpeptides.au/assets/coa/mots-c-40-coa.png?v=124 Full certificate library: https://www.australianresearchpeptides.au/coa ## Specifications | Property | Value | | --- | --- | | Scientific name | MOTS-c (mitochondrial ORF of the 12S rRNA type-c) | | Compound class | Mitochondrial-derived peptide; sixteen residues | | Appearance | White to off-white lyophilised powder | | Packaging | Sealed, tamper-evident glass vial | | Storage | Unopened, sealed vial kept dry below -15 °C; colder is better for long storage | ## About MOTS-C is studied in relation to energy metabolism, meaning how cells make and spend energy. Published work in mice and in cell culture reports it switching on AMPK, a protein that senses when a cell is short of fuel. Skeletal muscle looks like its main target tissue. This page names the research field and the measurements taken, and reports no outcome in a person. The peptide is coded by a short stretch of the 12S ribosomal RNA gene, which sits inside mitochondrial DNA rather than in the nucleus. Peptides coded that way are grouped together as mitochondrial-derived peptides. Humanin was the first of the group to be described, and MOTS-C followed it. The name is written and searched as MOTS-C, MOTSc and MOTS C. Lee and colleagues first described MOTS-C in 2015 in Cell Metabolism, identifying the reading frame it is coded from and the AMPK signalling pathway it was tested against in cells and in mice. ARP reports the existence of that published record and claims nothing about the material in its own vials. Australian Research Peptides lists MOTS-C in Australia as a 40 mg vial of freeze-dried powder, sealed in tamper-evident glass. It is searched as MOTS-C, MOTSc, MOTS C and the compressed motsc, and as a mitochondrial or longevity peptide. Stock is held locally and posted to every state and territory, so an order does not wait on an overseas consignment. The powder is assayed by HPLC, and the CoA library shows the certificate published for it. ## Questions ### Where to buy MOTS-C in Australia? Buy MOTS-C in Australia direct from Australian Research Peptides, who list it under code MOTSC in the Mitochondrial Research category — searchable as MOTS, motsc or mitochondrial derived peptide. It is listed as a 40 mg lyophilised vial. Weekday orders lodged before 12pm Sydney time go out that afternoon on tracked Standard or Express Post, reaching all states and territories. Parcels travel domestically only, never through customs, and the HPLC certificate is available on request. ### Where can I buy MOTS-C 40 mg in Australia? MOTS-C 40 mg is bought in Australia from Australian Research Peptides, which lists it in Mitochondrial Research and posts from within the country, so no order crosses a border. It is the only MOTS-C strength ARP lists: forty milligrams of the sixteen-amino-acid peptide under one seal. Its price and stock sit on the buying panel above rather than in this text, and the CoA library records the certificate published for it. ### What is MOTS-C? MOTS-C is a peptide of sixteen amino acids that mitochondria code for themselves. Almost every other peptide in a cell is coded by DNA in the nucleus. This one is coded by DNA inside the mitochondrion, the compartment that generates most of a cell's energy. Researchers first described it in 2015. Australian Research Peptides supplies it as a dry cake, for laboratory work only. ### What does the analytical testing on MOTS-C establish, and what does it not? Testing settles two things about MOTS-C. It shows what proportion of a batch sits under the main HPLC peak, and it shows the molecule weighs what the recorded sequence should weigh. The class descriptor mitochondria-derived peptide names where a peptide comes from, not what it is built from, so the mass check does real work on MOTS-C. A purity percentage belongs to the batch that was assayed rather than to the product line. ### What does MOTS-C stand for? MOTS-C stands for mitochondrial open reading frame of the 12S ribosomal RNA type-c. The name records a position in the genome rather than a chemical description. An open reading frame is a run of genetic code that can be read as instructions for a peptide, and MOTS-C is classed as a mitochondrial-derived peptide. ### How does MOTS-C work? MOTS-C is studied at AMPK, the switch a cell throws when energy runs short. [Lee's 2015 Cell Metabolism report](https://pubmed.ncbi.nlm.nih.gov/25738459/) describes it blocking part of the folate pathway, which builds up a molecule called AICAR, and AICAR turns AMPK on. [Kim 2018](https://pubmed.ncbi.nlm.nih.gov/29983246/), in the same journal, found that under metabolic stress the peptide also moves into the nucleus within about thirty minutes, where it binds antioxidant response elements — the stretches of DNA that switch stress-response genes on — and changes how strongly those genes are read. These are findings in cells and in mice. ### What does the research show about MOTS-C? Most MOTS-C work is done in cultured cells and in mice, and it is mechanistic rather than clinical. Lee and colleagues characterised the peptide in Cell Metabolism in 2015 and placed it on the AMPK signalling pathway; Reynolds and colleagues followed in Nature Communications in 2021, measuring the peptide in human muscle tissue samples. The published record stops at those model systems. None of that literature establishes anything about the research material on this page. ### Does MOTS-C come in tablets or a nasal spray? MOTS-C is not supplied as a tablet, a capsule or a nasal spray by Australian Research Peptides, which lists it only as a freeze-dried powder in a sealed glass vial. The published record on this peptide is built in cell culture and in animal models, not on an oral or intranasal preparation. No regulator anywhere has approved a MOTS-C product in any form, so no tablet exists as an approved medicine either. A pre-mixed presentation has also spent part of its stability window before it is posted, where a sealed lyophilisate starts that window when the researcher makes it up. ### What exactly is supplied in a MOTS-C vial? A MOTS-C vial holds freeze-dried peptide and nothing beside it. The solid is white to off-white, and all of it is the peptide rather than peptide spread through a filler. The glass is sealed under a tamper-evident cap. Nothing is dissolved, blended or split before dispatch, and the seal stays closed until a laboratory opens it. ### Has the clearance of MOTS-C been characterised? No pharmacokinetic profile has been published for MOTS-C — nobody has measured how fast it is absorbed, spread or cleared. Santhanam's 2026 rat-heart paper in Naunyn-Schmiedeberg's Archives of Pharmacology closes by calling for pharmacokinetic studies, which is an admission that none exist. Australian Research Peptides publishes no clearance figure and will not estimate one. What ARP does record for MOTS-C is its HPLC purity result. ARP's CoA library sets out which strengths have a certificate published against them. ### How many amino acids are in MOTS-C? MOTS-C is sixteen amino acids long, and the sequence [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/146675088) records for CID 146675088 runs Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg. Gao's 2023 review in Metabolites reports the first eleven positions as highly conserved between species. Residue is the technical word for one amino-acid unit in a chain, so sixteen residues and sixteen amino acids describe the same thing. Both Australian Research Peptides vial sizes hold that identical chain. ### Has MOTS-C ever been given to people in a clinical trial? No clinical trial has given MOTS-C itself to people. The trial usually cited in this context ran on CB4211, a modified analogue developed by CohBar — a separate molecule with its own record, none of which transfers to MOTS-C. Every human MOTS-C figure in the literature is a measurement of peptide people already make. Australian Research Peptides supplies MOTS-C for in vitro research and states no clinical finding for it. ### Does MOTS-C actually work? The published MOTS-C record stops at cultured cells and mice, so there is no clinical evidence to weigh either way. What exists instead is laboratory work on how the molecule behaves inside a cell, built around the AMPK signalling pathway, and it is a genuinely interesting molecule with real preclinical work behind it. Australian Research Peptides supplies the peptide for in vitro research and makes no claim about what it does. ### How long does MOTS-C take to work? No published study answers this, because the MOTS-C record stops at cultured cells and mice and nothing further has been measured. The animal and cell-culture literature tracks signalling changes over hours to weeks under laboratory conditions, which is a different question entirely. Any specific timeframe quoted for this compound is invented, and Australian Research Peptides does not quote one. ### What does the published literature record after MOTS-C exposure ends? It records nothing, because no published study has observed anything after exposure ended. Work on this mitochondrial peptide is barely a decade old and is confined largely to mice and cultured cells, all measured during the experiment itself. Nothing has been documented in either direction, and the candid position is that the question has never been examined. ### How do I pay for MOTS-C? A MOTS-C order is paid by PayID or bank transfer, and one reference belongs to one order rather than to one product. An order holding MOTS-C plus other products is a single reference and a single transfer. Reusing an old reference from a previous order sends the payment to the wrong place and needs manual unpicking before anything can be dispatched. ### How do I get told when MOTS-C is back in stock? MOTS-C is listed as one 40 mg vial, so a single alert covers it. Register on the product page and the email goes out when that vial is back in stock. ### Can MOTS-C be used alongside other peptides? MOTS-C is studied in mitochondrial and cellular energy pathways, which do not overlap with the incretin, growth-hormone or cell-signalling peptides Australian Research Peptides lists elsewhere. No study has combined it with any of them, so nothing is known about interactions in either direction — an absence of findings rather than a finding of safety. ### Is it normal for a MOTS-C vial to look empty? Yes — even the 40 mg MOTS-C vial holds a small pale cake rather than a vial full of powder. Sixteen amino acids of dried peptide simply do not fill much volume. No filler or carrier is added, which is precisely why so little sits there to look at. ### How long does a sealed MOTS-C vial last? Australian Research Peptides publishes storage conditions for MOTS-C rather than an expiry date, so no sealed shelf-life figure appears on this page and none should be carried across from a figure printed elsewhere. The storage panel gives the sealed dry vial two valid homes — frozen for the long term, or refrigerated for a few months — and gives a solution made up from it a shorter window of its own. Those are physical states rather than a choice between numbers. How long a correctly held lyophilisate lasts depends on the conditions it was actually kept in, which is why the conditions are what get published. ### How should MOTS-C be stored? MOTS-C carries two methionines and a tryptophan, and those amino acids oxidise more readily than the others. Bachem's handling guidance keeps a lyophilisate dry and tightly closed below -15 °C, and prefers colder again for the long term. Cold glass pulls water out of the air. Stand the sealed vial in a desiccator until it is no longer cold, then unseal it. Solutions keep poorly, so freeze them in single-use aliquots. ### How do you reconstitute MOTS-C? Add a suitable diluent to a MOTS-C vial and let the powder dissolve fully. Run the liquid in slowly and never shake the glass. MOTS-C is a basic peptide, so a mildly acidic buffer helps if water alone is slow to bring it into solution. Australian Research Peptides publishes no fill volume for the MOTS-C vial, because the volume added is what sets the concentration: the 40 mg vial reaches 10 mg/mL at 4 mL. ### How long does reconstituted MOTS-C keep? Once dissolved, MOTS-C gets a 2–8 °C fridge and no more than twelve weeks in it under Australian Research Peptides' storage panel. That window belongs to the solution alone; a sealed dry vial is a different state with its own rows on the same panel. MOTS-C holds two methionines plus a tryptophan, among the residues most readily oxidised, so it has more to lose to air and light than a shorter chain. Keep it dark throughout, and divide it rather than entering one vial repeatedly. ### Why is MOTS-C cloudy after mixing? Air is the ordinary culprit in a cloudy MOTS-C vial. Swirling or inverting it repeatedly forces bubbles through the liquid, and those scatter light indistinguishably from real turbidity before dispersing once everything is left alone. A 40 mg vial is a lot of solid, so it takes longer to finish clearing than a small fill would. Anything opaque beyond that, or grit which will not shift, is not simply bubbles. ### What is MOTS-C dissolved in for laboratory work? An aqueous diluent is normally used with a MOTS-C vial. In this context a diluent turns dry powder into something a pipette can move. Dry powder is all that sits inside the glass, with no water and no carrier beside it, and the volume added sets the concentration. ### Who supplies MOTS-C in Australia? MOTS-C reaches Australian buyers through Australian Research Peptides, which lists it in its Mitochondrial Research category, as a 40 mg vial, and reachable by searching mots c or mitochondrial derived peptide. Orders logged on a weekday before 12pm Sydney time are packed and posted the same day, and Express or tracked Standard Post covers every state and territory. No import leg, no customs queue. HPLC certificates issued on request; PayID or bank transfer. ### How much does MOTS-C cost in Australia? MOTS-C is priced by the vial in Australian dollars, with a separate figure against each strength rather than one price for the compound. Australian Research Peptides keeps every figure in the peptide's live catalogue entry, so none is a number frozen into prose — which also means the per-milligram rate on a larger vial can be read off the panel instead of taken on trust. Every MOTS-C strength holds the HPLC Verified grade. Postage is charged on top. ### Does a MOTS-C order qualify for free shipping in Australia? A MOTS-C order qualifies on its subtotal rather than on a vial count. Two 40 mg vials reach the free Standard tracked-post threshold, and the same two clear the higher Express waiver as well. Qualifying is judged on the list-price subtotal, before any code is applied. ### How to get MOTS-C online? MOTS-C is ordered directly from Australian Research Peptides rather than from a marketplace stall or a reseller. It is listed as a single 40 mg vial, with its stock shown live on the product page. Everything is packed and posted within Australia, which is why no MOTS-C order clears customs, and payment is settled by PayID or bank transfer. ### How long does MOTS-C take to arrive in Australia? MOTS-C is usually delivered 1–2 business days after lodgement when Express Post is selected, or 2–5 on standard tracked post. Ordering more than one strength still produces one parcel, one tracking number and one postage charge — items are not shipped separately or from different locations. That also means the whole order waits on the slowest line in it. ### What volume takes a 40 mg MOTS-C vial to 10 mg/mL? Four millilitres takes a 40 mg MOTS-C vial to 10 mg/mL, because the milligrams in the glass divided by the millilitres added gives the concentration. A smaller volume simply gives a stronger solution and a larger one a weaker solution, with the 40 mg of peptide unchanged. ### Is MOTS-C legal in Australia? Australian Research Peptides sells MOTS-C for in vitro research purposes only, and not as a medicine. It is not supplied for use in people or in animals, and no ARP material describes such use. MOTS-C is a research compound rather than an approved treatment, and it has not been assessed for that purpose. Anyone buying it takes responsibility for the rules that govern their own work. ### Is MOTS-C FDA approved? MOTS-C has been approved by no drug regulator in any country, and no registered medicine contains it. Lee and colleagues only described this mitochondrial-encoded peptide in 2015, so its scientific record is short and almost wholly preclinical, and none of it has been submitted for review. A vial of it is unregistered material intended for laboratory experiments. ### Is MOTS-C banned in sport? MOTS-C is prohibited in sport at all times, which is what a drug-testing question about it turns on. The World Anti-Doping Agency list names mitochondrial open reading frame of the 12S rRNA-c in full, unusually, grouping it with AICAR as an AMPK activator among the metabolic modulators. Prohibition applies in and out of competition alike. Sport Integrity Australia oversees testing for Australian athletes. ### Can you legally import MOTS-C into Australia? MOTS-C has never been put in front of a medicines regulator in any country, so an importer is bringing in a substance no agency has assessed rather than a foreign-approved product — the TGA's unapproved-goods rules apply and Border Force enforces them on arrival. Australian Research Peptides dispatches MOTS-C from Sydney, which removes the import leg altogether: a domestic parcel clears nothing, and that is why it reaches a buyer sooner than an overseas consignment. What that settles is the postal question. It does not change what the material is, nor what whoever holds it is answerable for. ### Is MOTS-C tested before it is supplied in Australia? No MOTS-C batch is sold untested. HPLC measures how pure the peptide is. Mass spectrometry checks that the mass matches a sixteen-amino-acid chain, and a chain missing even one amino acid weighs something different. No salt form is published, because it is not confirmed for this material. A matching certificate is currently published for this product and strength. ### What else is MOTS-C known as? MOTS-C has no separate development code or trade name. Registries index it under CAS 1627580-64-6, as a mitochondrial-derived peptide (MDP), and by its single-letter sequence MRWQEMGYIFYPRKLR. Buyers also type it compressed, as motsc or motsc10 with the vial size run straight on, and as MOTSc or MOTS C. It is sometimes nicknamed "exercise in a bottle" in headlines; that phrase is informal and does not establish a result, especially because nearly all the research described here is in rodents and the human studies measured the body's own MOTS-C. ### Is MOTS the same peptide as MOTS-C? Yes. Typed on its own, MOTS is how many people search for MOTS-C, and both reach the same sixteen-amino-acid peptide coded inside mitochondria. The dotted form m.o.t.s and the mistype mote c are searches for that same compound — ARP lists no other product under either of them. ### Why is MOTS-C called a longevity peptide? MOTS-C is called a longevity peptide because of where it is coded and what it is studied against, not because any study has shown supplied peptide extending a life. It belongs to the mitochondrial-derived peptides, and mitochondrial function is one of the standard axes of ageing research, so writers and sellers file it under longevity. The published MOTS-C work itself measures energy metabolism and AMPK signalling, in cultured cells and in mice. No lifespan result in a person stands behind the label. ### How does MOTS-C compare with retatrutide? MOTS-C differs from retatrutide in molecular target rather than in degree. Retatrutide is an incretin analogue — a copy of the gut hormones a meal releases — built around the GLP-1 receptor, and it also binds the GIP and glucagon receptors. MOTS-C is coded inside mitochondria, is sixteen amino acids long, and is studied instead at the signals a cell uses to manage its own fuel supply. Different molecular class, different receptor targets, different research areas. ### Does exercise raise MOTS-C? Exercise raises the body's own MOTS-C in the published human measurements. [Reynolds and colleagues, in Nature Communications in 2021](https://pubmed.ncbi.nlm.nih.gov/33473109/), recorded an 11.9-fold rise in skeletal muscle after exercise across ten volunteers. That is peptide a body makes for itself, measured in its own tissue — not a result in anyone given a vial. The distance between those two things is exactly where the "exercise in a bottle" nickname stops being accurate. ### How does MOTS-C compare with SS-31 and NAD+? MOTS-C, SS-31 and NAD+ are all studied in mitochondrial research and none of the three is the same kind of molecule. MOTS-C is the only one coded inside mitochondrial DNA: sixteen amino acids read from an open reading frame in the 12S rRNA gene, and studied as a signal about how a cell handles fuel. SS-31 is a four-residue synthetic peptide, designed and made rather than encoded by any genome. NAD+ is not a peptide at all — it is a coenzyme consumed in the reactions that release energy, so it is studied as a question of substrate supply. Australian Research Peptides supplies MOTS-C and SS-31 to laboratories and researchers, and lists NAD+ as well. ### What makes MOTS-C different from other longevity peptides? MOTS-C is the metabolic signal of the longevity group. Epitalon, GHK-Cu and SS-31 are studied against gene expression, extracellular-matrix signalling or mitochondrial protection, while the published MOTS-C work measures how a cell produces and spends energy. It therefore suits researchers whose interest is metabolic regulation, insulin signalling and exercise adaptation alongside ageing, rather than those looking only at the extracellular matrix, telomeres or inflammation. ### What strength does MOTS-C come in? MOTS-C from Australian Research Peptides comes in one strength, a 40 mg vial. The figure is the mass of freeze-dried powder in the glass, not a concentration or a purity level. Every vial holds the same sixteen amino acids in the same order, from the same mitochondrial coding origin. ### Is a 40 mg MOTS-C vial right for a small study? A 40 mg MOTS-C vial is the only size ARP lists, so the planning question is the refrigerated window rather than the per-milligram rate. Once made up, a vial keeps for a limited time, so 40 mg suits a long or multi-arm programme that will genuinely use it inside that window. One vial also means one lot number across the whole dataset. ### Can I buy MOTS-C at Chemist Warehouse? Australian Research Peptides lists MOTS-C; Chemist Warehouse does not stock it, and no pharmacy in any market does. The mitochondrial-derived peptide is not registered as a medicine anywhere in the world, which forecloses retail pharmacy supply everywhere rather than only in Australia. There is no prescription version either, because a prescription needs a registered product standing behind it. ARP offers it as a 40 mg research vial. ## Also searched as MOTS C, MOTSc ## Ordering - Standard post $12.99, free on orders over $199.00 - Express post $16.99, free on orders over $299.00 - Payment: PayID or bank transfer - Dispatched from within Australia; orders do not cross a border --- Product page: https://www.australianresearchpeptides.au/products/mots-c Shop: https://www.australianresearchpeptides.au/shop